Publication date
Fazia Brouri, Laurent Findji, Odile Médiani, Nathalie Mougenot, Naima Hanoun, Gilles Le Naour, Michel Hamon, Philippe Lechat
Toxic cardiac effects of catecholamines: role of β-adrenoceptor downregulation
Summary
The aim of our study was to analyse the mechanisms underlying cardiac toxicity caused by β-adrenoceptor stimulation and the relationships with their associated downregulation during heart failure. We used the experimental model of coronary artery ligation-induced myocardial infarction in male Wistar rats. In order to increase β-adrenergic stimulation, rats were subjected to a 15-day chronic isoprenaline administration (30 μg/kg/h). Isoprenaline administration induced haemodynamic inotropic compensation, almost abolished in vitro inotropic response to isoprenaline on papillary muscle (P