Orthopaedic service

Cruciate ligament disease or injury

The cranial cruciate ligament (CrCL) in dogs is the same as the “anterior” cruciate ligament (ACL) in humans. It is a band of tough fibrous tissue that attaches the femur (thigh bone) to the tibia (shin bone), preventing the tibia from shifting forward relative to the femur. It also helps to prevent the stifle (knee) joint from over-extending or rotating.

What is the cranial cruciate ligament?

Cruciate ligament disease or injury

The cranial cruciate ligament (CrCL) in dogs is the same as the “anterior” cruciate ligament (ACL) in humans. It is a band of tough fibrous tissue that attaches the femur (thigh bone) to the tibia (shin bone), preventing the tibia from shifting forward relative to the femur. It also helps to prevent the stifle (knee) joint from over-extending or rotating.

Trauma to the equivalent ligament in humans is common, and damage most frequently occurs during some form of sporting activity (including football, rugby and golf). The nature of cranial cruciate ligament disease is very different in dogs. Rather than the ligament suddenly breaking due to excessive trauma, it usually degenerates slowly over time, rather like a fraying rope. This important difference is the primary reason why the treatment options recommended for cruciate ligament injury in dogs are so different from the treatment options recommended for humans.

What is the cause of cruciate ligament injury in dogs?

In the vast majority of dogs, the cranial cruciate ligament (CrCL) ruptures as a result of long-term degeneration, whereby the fibres within the ligament weaken over time. We do not know the precise cause of this, but genetic factors are probably most important, with certain breeds being predisposed (including Labradors, Rottweilers, Boxers, West Highland White Terriers and Newfoundlands). Supporting evidence for a genetic cause was primarily obtained by assessment of family lines, coupled with the knowledge that many animals will rupture the CrCL in both knees, often relatively early in life. Other factors such as obesity, individual conformation, hormonal imbalance and certain inflammatory conditions of the joint may also play a role.

How can I tell if my dog has cruciate ligament disease?

Limping is the commonest sign of CrCL injury. This may appear suddenly during or after exercise in some dogs, or it may be progressive and intermittent in others. Some dogs are simultaneously affected in both knees, and these dogs often find it difficult to rise from a prone position and have a very “pottery” gait. In severe cases, dogs cannot get up at all and can be erroneously suspected of having a neurological problem.

What is happening inside an affected joint?

Fraying of the ligament triggers a cascade of events resulting in knee pain and lameness. At the earliest stage, osteoarthritis is already present. It’s important to accept this, because many people ask “when will my dog get osteoarthritis?” when in fact the dog has it already. At a critical point of fraying, the CrCL loses its normal mechanical function and painful lameness is accompanied by a mechanical lameness. At this point, one of the factors influencing the mechanical lameness is the shape of the top of the tibia (shin bone) that has a pronounced backwards slope in dogs. The consequence of this slope in dogs with an incompetent CrCL is that the femur will roll down the slope every time weight is taken on the leg. In dogs without impairment of the CrCL, this slope will only become a problem if it is very steep indeed and can predispose to CrCL problems.

Mechanics of cruciate disease

In some dogs, the mechanical deficiency can result in trauma to other structures within the joint, in particular, a pair of buffer cartilages known as menisci. In slipping down the slope of the top of the tibia, the femur can crush and tear these cartilages, particularly the one on the inside (medial aspect) of the joint.

How is cranial cruciate ligament injury diagnosed?

Diagnosis in dogs with complete rupture of the CrCL is usually based on examination by an experienced orthopaedic surgeon, with demonstration of laxity of the joint by specific manipulations of the knee. In dogs with partial tears or early degeneration of the ligament, other tests may be necessary, including radiography (x-rays) or MRI scans. To be of maximum benefit, radiographs must be of optimal quality. In most dogs, exploratory surgery or arthroscopy (keyhole surgery) is used to confirm the diagnosis and to investigate for possible cartilage tears or other problems.

How is cruciate ligament injury treated?

Non-surgical management

Non-surgical management is seldom recommended, except where the risks of a general anaesthetic or surgery are considered excessive (e.g. patients with severe heart disease, uncontrolled hormonal disorders or immune conditions, etc.). The cornerstones of non-surgical treatment are bodyweight management, physiotherapy, exercise modification and medication (anti-inflammatory painkillers). These same techniques are also important in the short-term management of dogs who are treated surgically, although the primary surgical aim is to minimise the requirement for long-term exercise restriction and medication. Dogs greater than 15kg have a very poor chance of becoming clinically normal with non-surgical treatment. Dogs weighing less than 15kg and cats have a better chance, although improvement usually takes several months and is rarely complete.

At Fitzpatrick Referrals, we are able to provide you and your dog with a rehabilitation plan for cruciate ligament disease. This is coordinated through our rehabilitation service whereby we have a team of chartered physiotherapists and hydrotherapists all very experienced in the management of cruciate ligament disease. Your orthopaedic clinician will coordinate an appointment with one of our chartered physiotherapists whereby a thorough clinical examination will be performed and a rehabilitation plan will be uniquely designed for your dog including a home exercise plan for you to follow at home. Most appointments are attended as an out-patient and your chartered physiotherapist will regularly evaluate your dog’s progress and amend your home exercise plan as necessary.

Surgical management

Surgical treatments are categorised into techniques that aim to replace the deficient ligament and those that render the ligament redundant by cutting the tibia and re-aligning the forces acting on the stifle joint.

Ligament replacement techniques

Various surgical techniques that mimic the procedures used for ligament replacement in humans have been practised for more than five centuries. In dogs, techniques using transfer of local tissues have the poorest chance of returning limb function to nearly normal or normal. This is probably because the replacement tissues are not as robust as the original ligament and they are positioned in the same unfavourable biomechanical environment that caused the original ligament to fail in the first instance.

Prosthetic ligament replacement techniques have also been used for many years. These are simple techniques that have the ability to return many animals to nearly normal function. The primary disadvantages of these techniques are their unpredictability during the early stages of recovery and mechanical limitations in heavy and athletic dogs. Some dogs become transiently more lame before improvement occurs. Others take many weeks to improve and a proportion will have ongoing knee instability and pain. Variations of this technique are most commonly recommended for dogs with traumatic cruciate ligament injuries and in animals where several stabilisers of the knee are damaged, so-called “multiligamenous injuries”.

For decades, sutures of nylon with various knotting and crimping systems have been placed between a bone at the back of the femur (the fabella) and a tunnel in the top of the tibia. These so-called fabello-tibial tuberosity sutures have had variable reported success rates dependent on material and technique. The most important aspect of this technique is that the ligament origin on the femur and insertion on the tibia are as isometric as possible, i.e. stay as far as possible the same length in flexion and extension. In reality, this is impossible and so the principle has been referred to as “quasi-isometry”. High success rates have been reported for the Arthrex “TightRope™” technique which uses a synthetic material called Fibretape™ or Fibrewire™ on metallic anchors placed through bone tunnels in the femur and the tibia. In patients where we adopt ligamentous replacement, this is the commonest technique we employ for this purpose.

Treatments that render the cranial cruciate ligament redundant

These surgeries alter the geometry of the affected knee joint in such a way that the CrCL is no longer necessary to maintain stability. There are several variations in technique, with all involving reshaping of the top of the shin (tibia) by cutting of the bone and fixing it in a new position. At Fitzpatrick Referrals, we offer the tibial plateau levelling osteotomy (TPLO) technique.

Tibial plateau levelling osteotomy (TPLO)

This surgery involves the creation of a radial cut in the top of the tibia and rotation of the plateau segment until the previous slope in the bone is no longer present. The bone is subsequently fixed in this new position using a bone plate and screws.

TPLO thrust from Fitzpatrick Referrals on Vimeo: This video illustrates what happens when a TPLO is performed.

Tibial tuberosity advancement (TTA)

This surgery follows the same principle as TPLO, with a cut being created in the tibia to allow a change in geometry that renders the CrCL redundant. The mathematical principles behind TTA are more complex than those behind TPLO; however, the basic principle is that an altered direction of traction from the quadriceps muscle group produces a force across the knee joint that neutralises the tendency for the femur to roll down the slope of the tibial plateau. In effect, both TTA and TPLO aim to render the tibial plateau perpendicular to the straight patellar tendon and in so doing, neutralise the tendency for the femur to slip down the slope of the tibia.

TTA thrust from Fitzpatrick Referrals on Vimeo: This video illustrates what happens when a TTA is performed.

What are the advantages of surgeries like TPLO and TTA that involve cutting of bone?

Because bone healing is more efficient than ligament healing, these repairs have a reputation for being significantly more robust than surgeries designed to replace the damaged ligament. The major practical benefit is a very reliable return of limb use, with all dogs expected to start weight bearing on the operated limb within 1-3 days. The mechanical advantages of TPLO and TTA coupled with the rapid return to function is especially important for heavy dogs, athletic animals, animals presenting with mild lameness (where ligament replacement could make them significantly more lame initially), and in animals with CrCL injuries affecting both stifle joints. In some animals with CrCL injuries that simultaneously affect both knees, TPLO can be performed on both stifles in a single surgery. Fitzpatrick Referrals have published a large case series documenting efficacy in this regard. This is not possible when using ligament replacement techniques.

At Fitzpatrick Referrals, our preferred technique is TPLO, which we carry out routinely.

CrCL rupture
TPLO neutralises abnormal force
TTA neutralises abnormal force

Are keyhole surgical techniques employed for the management of cruciate ligament injuries?

We have developed a refined technique for arthroscopic (keyhole) examination of the stifle (knee) joint. This gives us a magnified panoramic view of the joint. All dogs have an inspection of the joint to assess whether secondary injuries to the buffer cartilages, known as menisci, have occurred (this is performed either arthroscopically or via open surgery). If an injury is found, this is treated surgically by meniscal trimming. Meniscal repair may be appropriate in selected circumstances.

What are the success rates of TPLO and TTA?

As a general rule, over 90% of dogs return to normal activity after TPLO or TTA. This generally means that dogs are so normal that owners are unable to detect lameness at home. We expect dogs to return to unrestricted exercise without any requirement for ongoing medications. Performance dogs including sniffer dogs and military patrol dogs are expected to return to work after these surgeries. The success rates for TPLO and TTA are very similar. At Fitzpatrick Referrals, we routinely use kinetic gait analysis by means of a force plate on which the dog walks, to give us objective parameters on how a dog is actually walking both before and after surgeries.

What are the potential problems or complications after cruciate ligament repair surgery?

Fortunately, complication rates are low when experienced surgeons perform cruciate ligament repair surgery. The two commonest complications are infection and mechanical complications. Infection is treated using antibiotics. In some cases, surgical irrigation is necessary and, in the worst cases where bacteria adhere to the implants, the implants must be removed after the bones have healed. In the vast majority of animals, the implants remain in place for life and cause no problems at all. Mechanical complications usually occur in dogs that exercise too much before the bones have healed (which takes about 6 weeks). Many mechanical complications are managed with rest alone, although some problems require surgical revision. A rare complication of late injury to the menisci (buffer cartilages) within the operated knee joint can require treatment using keyhole surgery. Other rare complications including sprains and strains around the knee joint can generally be managed using physiotherapy alone. Fitzpatrick Referrals has published a very large case series of TPLO surgeries with a very low complication rate and very few requiring subsequent intervention.

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