Methods γH2AX and p53 expression were determined in biopsy samples of FISS. γH2AX expression was determined via immunohistochemistry whereas p53 expression was determined via qRT-PCR. Cell lines derived from these sarcoma biopsies were then treated with carboplatin (N = 11) or doxorubicin (N = 5) and allowed to grow as colonies. Colony forming-ability of cells exposed to chemotherapy was […]
Veterinary Medicine: Oncology
Soft tissue sarcoma in the dog – Part 2: surgical margins, controversies and a comparative review
Conclusion In 1981, it was recognised that the “biologic aggressiveness of a STS is the key factor in the selection of the surgical margin required to achieve local control” (Enneking et al. 1981). Almost half a century later, we continue to struggle with the same dilemmas in the management of canine STS. Because there are […]