A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels

Publication date 23rd March 2018
Authors F Ancot, P Lemay, S P Knowler, K Kennedy, S Griffiths, G B Cherubini, J Sykes, P J J Mandigers, G A Rouleau, Clare Rusbridge, Z Kibar


Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex developmental malformation of the skull and craniocervical vertebrae called Chiari-like malformation (CM)characterized by a conformational change and overcrowding of the brain and cervical spinal cord, particularly at the craniocervical junction. CM and SM have a polygenic mode of inheritance with variable penetrance.