A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels

Summary

Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex developmental malformation of the skull and craniocervical vertebrae called Chiari-like malformation (CM)characterized by a conformational change and overcrowding of the brain and cervical spinal cord, particularly at the craniocervical junction. CM and SM have a polygenic mode of inheritance with variable penetrance.

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