Noel Fitzpatrick, Thomas J. Smith, Catherine J. Pendegrass, Russell Yeadon, Michael Ring, Allen E. Goodship, Gordon W. Blunn
To report clinical application of intraosseous transcutaneous amputa- tion prosthesis (ITAP) for limb salvage.
Distal limb amputation allowed press-fit insertion of the ITAP into the radius (n = 3) or tibia (1). Remaining soft tissues including skin were at- tached directly to the ITAP. Limb stump and ITAP were protected by bandaging (1) or external skeletal fixation (3) for 5–6 weeks before exoprosthesis attachment. Measures of outcome included subjective assessments of limb function by owners and veterinarians, radiographic (4) and histologic (1) examination.
DermalintegrationwiththeITAPwasachievedby3weeksanddogswere walking in a pain-free manner by 8 weeks. One dog was administered adjunctive carboplatin chemotherapy. No evidence of local tumor recurrence occurred. In 1 dog, ITAP fracture occurred at 10 weeks and was successfully managed by ITAP replacement. Three dogs were euthanatized because of confirmed or assumed metastatic disease at 8, 12, and 17 months. Histologic examination of the ITAP- limb interface at 1 year documented osseous and dermal integration.